Metabolic Effects of Treatment With Atypical Antipsychotics

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The metabolic effects of treatment with antipsychotic medications have been under considerable debate. The main purpose of this discussion is to allow readers to get a sense of the information that is available regarding metabolic effects and the studies that are underway to expand this information (Appendix 1). The knowledge base about metabolic effects is evolving, so some of the conclusions drawn in this discussion may be tentative. For a list of antipsychotic medications affected by the FDA’s recent request for a labeling change, see Table 1.

J Clin Psychiatry 2004;65(11):1447-1455