The article you requested is
The Importance of Subsyndromal Symptoms in Bipolar Disorder
J Clin Psychiatry 2004;65(suppl 10):24-27
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Bipolar disorder continues to be characterized by poor clinical and functional outcomes in many
patients. Poor outcomes may be related to subsyndromal symptoms, defined as symptoms that fail to
meet the full diagnostic criteria for a mood episode. Several recent studies indicate that subsyndromal
symptoms in bipolar disorder are strongly associated with deficits in both social and occupational
functioning. Furthermore, subsyndromal symptoms appear to increase the risk of relapse. Combined,
these factors emphasize the importance of aggressive treatment strategies at the onset of subsyndromal
symptoms. In addition, the use of subsyndromal symptoms to broaden the diagnostic criteria
for bipolar disorder is receiving increased attention. This article reviews and discusses these important