Clinical and Demographic Features of Atypical Depression in Outpatients With Major Depressive Disorder: Preliminary Findings From STAR*D.[CME]
J Clin Psychiatry 2005;66:1002-1011
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Objective: To determine the frequency and
demographic and clinical characteristics of depression with
atypical features in a broadly representative sample of
Method: Data derived from the first 1500
patients with DSM-IV major depressive disorder enrolled in the
Sequenced Treatment Alternatives to Relieve Depression trial at
41 primary care and nonresearch psychiatric outpatient clinics.
An algorithm based on the 30-item Inventory of Depressive
Symptomatology-Clinician Rating (IDS-C30) determined presence or
absence of depression with atypical features. Odds ratios
determined whether a variety of demographic and clinical
parameters differed between patients meeting and not meeting
Results: Over 18% of the sample met criteria for
atypical features based on items from the IDS-C30. The atypical
group was more likely to be female and have an earlier age at
onset, greater comorbidity with anxiety symptoms, and greater
symptom severity compared with the nonatypical group.
Conclusion: Previously identified features of
atypical depression were confirmed in this large and broadly
representative, nonresearch clinical population.