Introduction: The Burden of Bipolar Depression

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Bipolar disorder is a common, debilitating illness that is associated with significant morbidity and mortality.1 Depression is the predominant mood symptom expressed in patients with bipolar disorder, with most patients having clinically significant depressive symptoms about 3 times longer than manic symptoms.2,3 Despite this, bipolar depression is often underrecognized or misdiagnosed as major depressive disorder (unipolar depression).​​

J Clin Psychiatry 2005;66(suppl 5):3-4