Lifetime Comorbidity of DSM-IV Mood and Anxiety Disorders and Specific Drug Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions
J Clin Psychiatry 2006;67(2):247-258
© Copyright 2016 Physicians Postgraduate Press, Inc.
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Objective: To present nationally
representative data on the lifetime prevalence and
comorbidity of 8 specific drug use disorders, separately
for abuse and dependence, and mood and anxiety disorders.
Method: Data come from a
representative sample (N = 43,093) of the United States
civilian, noninstitutional population 18 years and
older. Diagnoses of mood, anxiety, and drug use
disorders were based upon face-to-face personal
interviews using the Alcohol Use Disorder and Associated Disabilities Interview
Schedule-DSM-IV Version (AUDADIS-IV).
Results: Associations between specific
mood and anxiety disorders and specific drug use
disorders were virtually all positive and
statistically significant (p < .05). In general, associations
were greater for dependence than abuse, greater
for mood than anxiety disorders, and in some instances stronger among women than men
(p < .05). Large odds ratios also were observed for
individuals with comorbid mood and anxiety disorders.
Conclusion: The comorbidity between
specific mood and anxiety disorders and specific drug use disorders is pervasive in the U.S.
population. Findings suggest that comorbid
psychiatric disorders may increase the risk of greater
involvement in more serious illicit drug use disorders
and that the greater comorbidity between mood and anxiety and drug use disorders among
women may reflect greater deviance and
psychopathology among drug-using women than men.
Findings also suggest that drug abuse prevention
and intervention efforts should address other
psychiatric conditions. Further, definitions of drug
use disorder phenotypes should give careful
consideration to other psychiatric conditions as
meaningful characteristics of case heterogeneity.