Outcomes of Late-Life Anxiety Disorders During 32 Weeks of Citalopram Treatment
J Clin Psychiatry 2006;67(3):468-472
© Copyright 2015 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: Anxiety disorders are
common in later life, but little is known about the
long-term benefits and risks of pharmacotherapy.
Method: 30 patients aged 60 years and
older, with a DSM-IV anxiety disorder, entered a
32-week trial of citalopram. Data gathered at baseline and follow-up included anxiety
symptoms using Hamilton Rating Scale for Anxiety
(HAM-A) scores, quality of life using the Medical
Outcomes Study 36-item Short Form (SF-36), and sleep using the Pittsburgh Sleep Quality
Index (PSQI). Data analysis consisted of
mixed-effect repeated measures models of HAM-A scores
and pre-post comparison of SF-36 and PSQI scores.
Results: 30 persons entered treatment;
most (27/30) had a primary DSM-IV diagnosis of generalized anxiety disorder (2 had panic disorder;
1 had posttraumatic stress disorder). Three
subjects discontinued study medication due to side
effects, 5 were terminated because of nonresponse, and
5 dropped out of the study for other reasons;
thus, 17 subjects (57%) completed 32 weeks of
treatment. Subjects' HAM-A scores improved significantly, with continuing improvements up
until about 20 weeks of treatment. On the basis of
a criterion of reduction in HAM-A to < 10 during the trial, 60% (18/30) of subjects were
responders. Those who completed the 32-week trial
had significant improvements in sleep and quality
of life-including social functioning, vitality,
mental health, and role difficulties due to
Conclusions: In this 32-week study of
citalopram for elderly persons with anxiety
disorders, 60% responded. Those who received a full
course of treatment experience significant
improvements in quality of life and sleep quality.