Efficacy of Ziprasidone Against Hostility in Schizophrenia: Post Hoc Analysis of Randomized, Open-Label Study Data
J Clin Psychiatry 2006;67(4):638-642
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Objective: The objective was to determine
the effects of sequential intramuscular/oral ziprasidone on hostility.
Method: A total of 572 inpatients
diagnosed with DSM-IV schizophrenia or
schizoaffective disorder were the subjects in a randomized,
rater-blinded, 6-week, open-label study comparing
sequential intramuscular and oral ziprasidone with haloperidol. The Brief Psychiatric Rating
Scale (BPRS) was the principal outcome measure. To determine the effect of ziprasidone on
hostility, post hoc analyses of scores on the hostility
item from the BPRS were conducted. Introducing
positive symptoms and akathisia as covariates tested specific antihostility effect. The study
was conducted from October 23, 1998, to August 15, 2000.
Results: Ziprasidone demonstrated
specific antihostility effects over time throughout the 42-day study period and statistically significant superiority to haloperidol on this measure in
the first week of treatment (p = .0149 at first
evaluation [day 1, 2, or 3]; p = .0358 at day 7).
Conclusion: Ziprasidone is an effective
treatment for hostility in patients with
schizophrenia or schizoaffective disorder.