Risperidone-Induced Hyperprolactinemia in Adolescents: A Case Series
Subramoniam Madhusoodanan, MD, and Despina Moise, MD
J Clin Psychiatry 2006;67(7):1110-1113
© Copyright 2016 Physicians Postgraduate Press, Inc.
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Objective: To study the effect of
risperidone on prolactin levels in 3 adolescent patients.
Method: This is a case study of 3
adolescent patients with DSM-IV diagnosis of
schizophreniform disorder, major depressive disorder
with psychotic features, or chronic
undifferentiated schizophrenia who were treated in inpatient
and outpatient psychiatric settings with risperidone. Patients developed hyperprolactinemia with
clinical symptoms. Risperidone was discontinued gradually over 2 weeks, and patients were
treated with other atypical antipsychotics.
Results: Prolactin levels returned to
normal, and clinical symptoms of hyperprolactinemia
resolved in all 3 patients after 2 weeks of
tapering and discontinuation of risperidone.
Conclusion: Hyperprolactinemia can be
a troublesome side effect with potentially serious complications. It is being increasingly reported
in younger patients treated with risperidone.
Recognition and treatment of this condition
including switching to a prolactin-sparing agent are
important to prevent this complication.