A 100-Year Update on Alzheimer's Disease and Related Disorders

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This month marks the 100th anniversary of the scientific presentation in which Dr. Alois Alzheimer described the clinical and neuropathologic features of the disease that now bears his name.1,2 In this issue of The Journal of Clinical Psychiatry, our “Focus on Alzheimer’s Disease and Related Disorders” section commemorates this historic event with the publication of a review article on Alzheimer’s disease. Richard Caselli, Thomas Beach, Roy Yaari, and I consider the clinical and neuropathologic features, evaluation, and management of Alzheimer’s disease; known genetic risk factors and suggested pathogenic mechanisms; and some of the promising disease slowing and prevention strategies that remain to be rigorously tested.​​

J Clin Psychiatry 2006;67(11):1782-1783