The article you requested is
Prospective Studies of Adverse Events Related to Antidepressant Discontinuation.
J Clin Psychiatry 2006;67(suppl 4):14-21
© Copyright 2014 Physicians Postgraduate Press, Inc.
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The value of a prospective assessment of discontinuation-emergent symptoms proximal to the termination
of antidepressant treatment cannot be overstated. Though varying in frequency and intensity,
nearly all classes of antidepressants have been linked with discontinuation reactions and the associated
psychological, physical, and somatic discomfort. Spontaneous reports have been typically used
to gauge the risks of discontinuation reactions. Judging from a number of prospective studies, spontaneous
reports very likely underestimate the occurrence of discontinuation reactions. This probability
suggests that systematic inquiry must urgently become a part of the assessment in antidepressant discontinuation
studies. Insight into the number and type of events that may occur following antidepressant
discontinuation may be gleaned from instruments such as the Discontinuation-Emergent Signs
and Symptoms Scale. This article takes a comprehensive view of a number of studies dealing with
discontinuation-related adverse events. It discusses key issues in the analysis of incidence rates of
antidepressant discontinuation–emergent adverse events such as the obvious bias of both clinicians’
and patients’ being aware of the treatment discontinuation. This article also looks at early prospective
studies of antidepressant discontinuation reactions based on spontaneous reports and discusses, while
making the case for, prospective studies based on systematic inquiry.