The article you requested is
Symptoms of Fatigue and Sleepiness in Major Depressive Disorder
J Clin Psychiatry 2006;67(suppl 6):9-15
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Fatigue and sleepiness (hypersomnia) are symptoms that are highly prevalent in patients with
major depressive disorder (MDD). Individuals who complain of fatigue but do not have diagnosable
depression are at a higher risk for developing MDD later in life than individuals who do not complain
of fatigue. Fatigue and sleepiness also appear to be particularly difficult to treat, as they are often encountered
as residual symptoms among MDD patients who have remitted following treatment with
standard antidepressants. There are 3 main approaches for addressing fatigue and sleepiness in depression:
first, prescribing antidepressant medications that are less likely to exacerbate these particular
symptoms; second, prescribing antidepressant medications that are more likely to resolve these
symptoms; third, the use of adjunctive treatments to specifically target residual fatigue and sleepiness