Augmenting Antidepressants With Folate: A Clinical Perspective.
J Clin Psychiatry 2007;68(suppl 10):4-7
© Copyright 2014 Physicians Postgraduate Press, Inc.
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The goal of treatment of depression is full remission, but only a minority of patients will achieve
full remission with antidepressant monotherapy. Several forms of augmentation have been found to
improve the effect of antidepressants, but in some cases, issues of safety and tolerability may be of
concern. Folate in particular has been found to further reduce symptoms in patients with depression
when used in conjunction with an antidepressant, and because folate is a water-soluble B vitamin, its
safety and tolerability are well established. This strategy would typically be used in patients with low
plasma or red blood cell folate levels. Folate augmentation may be used (1) to enhance the efficacy of
antidepressants in nonresponders, (2) to enable those who partially respond to antidepressant monotherapy
to achieve remission, and (3) to alleviate residual symptoms during antidepressant treatment.