The article you requested is
Augmentation Strategies to Increase Antidepressant Efficacy
J Clin Psychiatry 2007;68(suppl 10):18-22
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Augmentation strategies for the treatment of major depressive disorder (MDD) are needed when
patients with MDD have not tolerated or responded to antidepressant monotherapies. Clinicians can
employ sequenced treatment steps, preferably coupled with the use of a treatment algorithm, to utilize
augmentation strategies that will enable patients to achieve remission. The focus of augmentation
therapy has been combining an antidepressant medication with another antidepressant; however,
atypical antipsychotics are becoming commonly used to augment antidepressants. Beyond antidepressants
and antipsychotics, alternative augmentation strategies include emerging pharmacologic
treatments and nonpharmacologic strategies.