Olanzapine or Lamotrigine Addition to Lithium in Remitted Bipolar Disorder Patients With Anxiety Disorder Comorbidity: A Randomized, Single-Blind, Pilot Study
J Clin Psychiatry 2008;69(4):609-616
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Objective: The aim of the present randomized, single-blind,
pilot study was to assess the efficacy of the addition of a second mood
stabilizer, either olanzapine or lamotrigine, to lithium in patients with
remitted bipolar disorder and comorbid anxiety disorder.
Method: Adult DSM-IV bipolar disorder patients with a current
anxiety disorder and a Hamilton Rating Scale for Anxiety (HAM-A) score of 12 or
higher, in remission from an affective episode for at least 2 months while on
lithium maintenance treatment, were randomly assigned to receive 12 weeks of
single-blind olanzapine 5 to 10 mg/day (N = 24) or lamotrigine 50 to 200 mg/day
(N = 23) addition to lithium. The primary outcome measure was the HAM-A;
secondary outcome measures were the Clinical Global Impressions-Severity of
Illness scale and the Global Assessment of Functioning (GAF) scale. Data were
collected from July 2005 to February 2007.
Results: Twenty-two patients in the olanzapine and 18 in the
lamotrigine group completed the trial. Mean ± SD final doses of olanzapine and
lamotrigine were, respectively, 7.7 ± 4.2 mg/day and 96.7 ± 46.7 mg/day in the
intent-to-treat sample (N = 47). Both olanzapine and lamotrigine were effective
in reducing HAM-A scores from baseline to endpoint (paired t test for
completers: t = 11.361, df = 21, p < .001 for olanzapine and t = 6.301, df =
17, p < .001 for lamotrigine). Both drugs were also effective on the secondary
outcome measures. Olanzapine was more effective than lamotrigine at weeks 6 and
12 with a last-observation-carried-forward analysis on all 3 outcome measures,
while such differences disappeared on the HAM-A and GAF at week 12 with the
Conclusions: The addition of a second mood stabilizer (olanzapine
or lamotrigine) to lithium is effective in reducing anxiety symptoms in bipolar
disorder patients with a co-occurring anxiety disorder.