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ASCP Corner: Are Antidepressants Effective? What’s a Clinician to Think?

J Clin Psychiatry 2008;69(6):1014-1015

Questions about the efficacy of antidepressant drugs in depression have been raised as a result of 2 recent reports. Turner et al. reviewed industry-sponsored clinical trials (randomized controlled trials; RCTs) submitted to the FDA and found that positive RCTs were more likely to be subsequently published than negative trials. The authors suggested that published data overestimate the effectiveness of antidepressants.

Abstract