ASCP Corner: Sequenced Treatment Alternatives to Relieve Depression (STAR*D): Lessons Learned
J Clin Psychiatry 2008;69:1184-1185
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.
Sequenced Treatment Alternatives to
Relieve Depression (STAR*D), the largest
prospective, randomized antidepressant
treatment trial to date in outpatients with
major depressive disorder (MDD) recruited
from real-world clinical settings, enrolling
4011 outpatients aged 18 to 75 years with
nonpsychotic MDD. Designed to determine
which treatments are most effective after
nonremission or intolerance to an initial selective
serotonin reuptake inhibitor (SSRI),
or to any of a series of subsequent randomized
treatments, STAR*D was conducted
in 18 primary and 23 psychiatric care settings
across the United States. This review
summarizes unique features of the study,
initial remission rates and associated participant
characteristics, remission rates for
subsequent treatment steps, relapse rates
during follow-up, and clinical implications.