Atypical Antipsychotics in Children and Adolescents With Autistic and Other Pervasive Developmental Disorders
J Clin Psychiatry 2008;69(suppl 4):15-20
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Atypical antipsychotics are emerging as the first-line pharmacologic
treatment for irritability (i.e., aggression, self-injurious behavior, and
severe tantrums) in children and adolescents with autistic and other pervasive
developmental disorders. Results from placebo-controlled and open-label
studies of clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and
aripiprazole in this subject population are reviewed. Additional
placebo-controlled trials and studies of longer-term safety and tolerability