Predictors of Longitudinal Changes in Schizophrenia: The Role of Processing Speed
J Clin Psychiatry 2009;70(6):888-896
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Background: The main objective was to identify variables that predict functional disability in chronic schizophrenia over time.
Method: We examined 95 hospitalized patients with schizophrenia (DSM-IV criteria) in a long-stage unit and 53 healthy controls (matched for age, gender, and years of education). Neuropsychological battery included tests for verbal memory, working memory, executive functioning, and processing speed. Functional disability was assessed at 6-month follow-up with the Disability Assessment Schedule after the neuropsychological and clinical assessment. The study was conducted from September 2005 to July 2008.
Results: Patient performance was significantly lower than that of the healthy comparison subjects on all neurocognitive variables (p
Conclusion: Processing speed plays an outstanding role in the relationship between neurocognitive symptoms and self-care, vocational outcome, and social functioning. Our data support the possibility of processing speed as the best longitudinal predictor of the level of autonomy in patients with chronic schizophrenia.