Generalized Anxiety Disorder and Psychiatric Comorbidities Such as Depression, Bipolar Disorder, and Substance Abuse
J Clin Psychiatry 2009;70(suppl 2):10-14
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Generalized anxiety disorder (GAD) has a high rate of comorbidity with other psychiatric disorders,
including major depressive disorder (MDD), bipolar disorder, other anxiety disorders, and substance
use disorders. The similarities between GAD and MDD have led some to suggest that GAD
should be reclassified as a mood disorder. The concurrence of GAD with another disorder heightens a
patient’s risk for impairment, disability, and suicidality. Clinical trials for GAD and disorders that are
most likely to occur with GAD have generally not taken comorbidity into account, and there is a paucity
of data guiding how comorbidity should inform treatment selection.