First-Line Pharmacotherapy Approaches for Generalized Anxiety Disorder.
J Clin Psychiatry 2009;70(suppl 2):25-31
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Many patients with generalized anxiety disorder (GAD) do not receive adequate treatment.
Several classes of drugs, including benzodiazepines, azapirones, selective serotonin reuptake inhibitors,
serotonin-norepinephrine reuptake inhibitors, antihistamines,α2δ Ca++ channel modulators, and
atypical antipsychotics are consistently beneficial in patients with GAD. Cognitive therapy is also effective
as a first-line treatment. When individualizing treatment, drug dose ranges and side effect profiles
need to be considered, as well as the patient’s comorbid conditions.