Leber’s Hereditary Optic Neuropathy Associated With Schizophrenia

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Leber’s hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease characterized by bilateral visual loss of central vision, generally affecting young men. Three main mutations of mitochondrial DNA (mtDNA) involved in complex I of the oxidative phosphorylation system have been reported, encompassing over 90% of patients: G3460A (genetic subunit ND1), G11778A (ND4), and T14484C (ND6). Mitochondrial oxidative phosphorylation is the major pathway producing adenosine triphosphatase (ATP), which supplies more than 95% of the total energy requirements in cells.

J Clin Psychiatry 2012;73(9):e1158-e1159