Case Report

AI-Associated Psychosis

Case Report

AI-Associated Psychosis

October 1, 2026

The authors present the case of a 27-year-old woman with psychosis, in whom the use of generative AI colored her clinical presentation.

Jamie Harbourd, Suresh Yadav, Kagan Temur, et al

Psychotherapy Based on a Buddhist Concept

Case Report

Psychotherapy Based on a Buddhist Concept

October 1, 2026

The author describes a perplexing case of a 14-year-old girl with autism and the use of a psychotherapeutic treatment intervention based on a Buddhist concept.

Takuji Inagaki

Worsening of Depression and Anxiety with Psilocybin

Case Report

Worsening of Depression and Anxiety with Psilocybin

September 30, 2026

A patient with undiagnosed cyclothymia, with a decade of depression, anxiety, and inattention, had severe worsening of depression and anxiety after a high-dose, lay-administered psilocybin session.

S. Nassir Ghaemi

Atypical Depression and OSA Screening

Case Report

Atypical Depression and OSA Screening

September 29, 2026

Young patients with atypical depression, marked weight gain, and snoring can go years without formal obstructive sleep apnea screening, contributing to underdiagnosis within psychiatric care.

Ana Lourenço, Marta Ribeiro

Kratom-Induced Serotonin Syndrome

Case Report

Kratom-Induced Serotonin Syndrome

September 24, 2026

A 38-year-old man on a stable regimen of psychotropic medication developed serotonin syndrome after heavy kratom use.

Talya Kapenstein, Alëna A. Balasanova

Esketamine For Depression in MS

Case Report

Esketamine For Depression in MS

September 22, 2026

This case of a 42-year-old man introduces intranasal esketamine as a potentially useful treatment option for depressive symptoms in a patient with multiple sclerosis.

Meghna Mathews, Genesy Aickareth, Anjal Abraham, et al

Olfactory Reference Syndrome Responding to Amisulpride

Case Report

Olfactory Reference Syndrome Responding to Amisulpride

September 17, 2026

The authors describe a case of olfactory reference syndrome in a 22-year-old woman, who presented with prominent referential beliefs and poor insight, closely resembling a first-episode psychosis.

João Revez Lopes, Carlos Siopa, Inês Simões

Lorazepam in Chronic Catatonia Reversal

Case Report

Lorazepam in Chronic Catatonia Reversal

September 10, 2026

This report describes chronic organic catatonia following cerebral malaria in a 17-year-old male, who experienced a marked response to lorazepam.

G. Shreya Eashwar, Lokesh Kumar Singh, Namish Kumar

When Obsession and Psychosis Become Indistinguishable

Case Report

When Obsession and Psychosis Become Indistinguishable

September 8, 2026

Differentiating obsessions from delusions is essential for accurate diagnosis and management, as comorbid obsessive-compulsive symptoms in schizophrenia complicate treatment and may influence cognitive and affective outcomes.

Marta Rebelo, Patrícia Baronet, José Abrantes, et al

Managing 7-hydroxymitragynine Withdrawal

Case Report

Managing 7-hydroxymitragynine Withdrawal

August 27, 2026

A 49-year-old man taking “7-OH” experienced signiﬁcant opioid withdrawal symptoms that resolved with high-dose buprenorphine-naloxone treatment.

Jacob T. Held, Francisco P. Varicat

Aripiprazole-Induced Hiccups

Case Report

Aripiprazole-Induced Hiccups

August 25, 2026

A 29-year-old man hospitalized for psychotic symptoms in the context of methamphetamine experienced persistent hiccups after starting aripiprazole.

Tingting Ge, Suresh Yadav, Chelsea Chen, et al

Renal Agenesis, Dysmorphism, and Schizophrenia

Case Report

Renal Agenesis, Dysmorphism, and Schizophrenia

August 18, 2026

The authors report a case of treatment-resistant schizophrenia with unilateral renal agenesis and minor physical anomalies, highlighting this rare association as well as treatment implications.

Anirudh Bakam, Rajdeep Birdi, Kanika Dhiman, et al

Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion

Case Report

Unexpected Improvement in Obsessive-Compulsive Disorder Symptoms Following Initiation of Bupropion

August 18, 2026

A 23-year-old woman with OCD and comorbid depression experienced an unexpected improvement in OCD symptoms following initiation of bupropion.

Juan Miguel Riestra, Zoya Munsar, Douglas J. Opler

Peduncular Hallucinosis With Right Thalamic Cavernous Angioma

Case Report

Peduncular Hallucinosis With Right Thalamic Cavernous Angioma

August 18, 2026

A 56-year-old woman developed visual and auditory hallucinations, delusions of jealousy and possession, and cognitive impairment associated with a thalamic lesion

Mizuki Kudo, Yuko Daa, Hirofumi Hirakawa

Volitional Mutism in Adulthood

Case Report

Volitional Mutism in Adulthood

August 6, 2026

The authors present a case of volitional mutism in a 42-year-old woman and highlight the differential diagnosis.

Garrett Hill, Gregory Noe, Sahil Munjal

Mushroom-Based Supplement Worsens Psychosis

Case Report

Mushroom-Based Supplement Worsens Psychosis

August 4, 2026

This case illustrates potential neuropsychiatric risks associated with mushroom-based dietary supplements in individuals with neurological vulnerabilities such as cerebral palsy.

Kirat Kaur, Shobit Garg

Testosterone-Induced Psychosis in Klinefelter Syndrome

Case Report

Testosterone-Induced Psychosis in Klinefelter Syndrome

July 30, 2026

The authors report a rare case of acute psychosis following long-term parenteral testosterone replacement in a patient with undiagnosed Klinefelter syndrome.

Abhijeet Anand, Shobit Garg

Abrupt Smoking Cessation With Tirzepatide

Case Report

Abrupt Smoking Cessation With Tirzepatide

July 30, 2026

The authors present a case of sudden, sustained smoking cessation associated with the initiation of tirzepatide in a 53-year-old woman.

Omar I. Ceesay, Blase Rokusek, Jordan Rasmussen, et al

Decision-Making Capacity in the Operating Room

Case Report

Decision-Making Capacity in the Operating Room

July 28, 2026

This case illustrates that patients may retain decision-making even when refusing life-sustaining interventions in emergent contexts

Greg Noe, Garret Hill, Hannah Lee, et al

Amiodarone-Induced Thyrotoxicosis and Mania

Case Report

Amiodarone-Induced Thyrotoxicosis and Mania

July 28, 2026

A 66-year-old man diagnosed with amiodarone-induced thyrotoxicosis who presented to the emergency department with symptoms of mania.

David R. Spiegel, Rachel Billingsly, Melissa Cazzell, et al

Modafinil for Hypoactive Delirium in the ICU

Case Report

Modafinil for Hypoactive Delirium in the ICU

July 21, 2026

A 57-year-old woman with severe hypoactive delirium rapidly improved following a split-dosing strategy of modafinil.

Austin J. Eason, Noelle Dorvault, Hope Bentley, et al

Mirtazapine-Induced Severe Hyponatremia

Case Report

Mirtazapine-Induced Severe Hyponatremia

July 16, 2026

A 30-year-old man developed severe hyponatremia after starting mirtazapine, highlighting the importance of closely monitoring sodium levels when starting any antidepressant in patients already taking oxcarbazepine.

Nathan R. Luzum, Sahil Munjal

Cocaine-Associated Rectal Foreign Body Insertion

Case Report

Cocaine-Associated Rectal Foreign Body Insertion

July 16, 2026

This case highlights how recurrent surgical presentations related to substance-associated compulsive behavior can outpace sustained, longitudinal behavioral intervention, particularly when psychiatric and addiction care are not integrated early.

Ann C. Schwartz, Ashley Smith, Caroline Stiles, et al

Freeze Attacks in Stiff Person Spectrum Disorder

Case Report

Freeze Attacks in Stiff Person Spectrum Disorder

July 14, 2026

A 43-year-old woman with stiff person spectrum disorder developed agoraphobia after "freeze attacks" in public, highlighting the need to screen these patients for anxiety and the role of CBT...

Drew Cumming, Gabriel Hastreiter, Justin Abbatemarco

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