Case Report

Modafinil for Hypoactive Delirium in the ICU

Case Report

Modafinil for Hypoactive Delirium in the ICU

July 21, 2026

A 57-year-old woman with severe hypoactive delirium rapidly improved following a split-dosing strategy of modafinil.

Austin J. Eason, Noelle Dorvault, Hope Bentley, et al

Mirtazapine-Induced Severe Hyponatremia

Case Report

Mirtazapine-Induced Severe Hyponatremia

July 16, 2026

A 30-year-old man developed severe hyponatremia after starting mirtazapine, highlighting the importance of closely monitoring sodium levels when starting any antidepressant in patients already taking oxcarbazepine.

Nathan R. Luzum, Sahil Munjal

Cocaine-Associated Rectal Foreign Body Insertion

Case Report

Cocaine-Associated Rectal Foreign Body Insertion

July 16, 2026

This case highlights how recurrent surgical presentations related to substance-associated compulsive behavior can outpace sustained, longitudinal behavioral intervention, particularly when psychiatric and addiction care are not integrated early.

Ann C. Schwartz, Ashley Smith, Caroline Stiles, et al

Freeze Attacks in Stiff Person Spectrum Disorder

Case Report

Freeze Attacks in Stiff Person Spectrum Disorder

July 14, 2026

A 43-year-old woman with stiff person spectrum disorder developed agoraphobia after "freeze attacks" in public, highlighting the need to screen these patients for anxiety and the role of CBT...

Drew Cumming, Gabriel Hastreiter, Justin Abbatemarco

Fluoxetine-Induced Liver Injury

Case Report

Fluoxetine-Induced Liver Injury

June 30, 2026

The authors report a case of fluoxetine-induced acute liver injury in a young woman to highlight the possibility of severe hepatic damage with a widely used antidepressant and emphasize...

Shushank Tej Tekupalli, Anirudh Bakam, Sai Spoorthy Mamidipalli, et al

Medical and Cultural Approach to OCD

Case Report

Medical and Cultural Approach to OCD

June 23, 2026

This case demonstrates successful management of severe religious OCD through medication optimization and psychotherapy over an 18-month treatment period.

Tirth Patel, Shady S. Shebak

Visual Snow Syndrome and Bupropion

Case Report

Visual Snow Syndrome and Bupropion

June 18, 2026

A patient in their 60s with advanced macular degeneration complicated by bilateral geographic atrophy presented with new-onset visual disturbances shortly after initiation of bupropion for depression.

Dax C. Volle

Zolpidem for Severe Insomnia Associated With Delirium in Critical Illness

Case Report

Zolpidem for Severe Insomnia Associated With Delirium in Critical Illness

June 11, 2026

A critically ill patient with sepsis and persistent delirium with treatment-refractory insomnia experienced rapid improvement in sleep continuity, delirium severity, and bedside cognitive performance with zolpidem.

Matthew Gunther, Jose R. Maldonado, Shixie Jiang

Catatonia Induced by D2R Antagonist Antiemetics

Case Report

Catatonia Induced by D2R Antagonist Antiemetics

June 4, 2026

The authors describe a rare case of catatonia correlated with abuse of D2R antagonist antiemetic medications in a 52-year-old man with multiple sclerosis.

Francisco S. Silva, Magda G. Lemos, Patrícia Baronet

Psychosis in Japanese Encephalitis

Case Report

Psychosis in Japanese Encephalitis

June 2, 2026

This case underscores the importance of considering viral encephalitis as a differential diagnosis for acute neuropsychiatric presentations associated with fever, particularly in patients residing in endemic areas.

Omar Afroz, Raja Babu Ramawat, Sharaz Ahmed, et al

Shared Possession Trance Disorder in 4 Children

Case Report

Shared Possession Trance Disorder in 4 Children

May 28, 2026

Four children from the same household experienced recurrent fainting episodes accompanied by changes in speech, facial expression, and mannerisms.

Rajith Ravindren, Suja Mathew

Ventilation Weaning, Anxiety, and Valproic Acid

Case Report

Ventilation Weaning, Anxiety, and Valproic Acid

May 28, 2026

The authors present the case of a man with Guillan Barre syndrome, whose mechanical ventilation weaning was prolonged, in part, by anxiety.

David R. Spiegel, Alex LaFever, Ryan Vazquetelles, et al

Scrambler Therapy for Neuropathic Pain

Case Report

Scrambler Therapy for Neuropathic Pain

May 26, 2026

Scrambler therapy is an innovative treatment option for patients with chronic neuropathic pain, especially for those who do not respond to conventional interventions.

Eliot Sadik, Brandon J. Goodwin, Ankur Jain, et al

ECT for Psychosis in Huntington Disease-Like 2

Case Report

ECT for Psychosis in Huntington Disease-Like 2

May 19, 2026

A 47-year-old woman with genetically confirmed Huntington disease-like 2 had refractory psychosis and functional decline but responded well to electroconvulsive therapy.

Jacob Kadan, Christopher Doxey, Gregory Noe, et al

Adjunct Memantine for Inappropriate Sexual Behavior

Case Report

Adjunct Memantine for Inappropriate Sexual Behavior

May 14, 2026

Two patients with intellectual disability and major neurocognitive disorder exhibited inappropriate sexual behavior that significantly decreased after memantine was added as adjunctive therapy.

Zeba Hasan Hafeez, Ida Jahed

From Physical to Digital: Hoarding Phenomena in Obsessive-Compulsive Disorder

Case Report

From Physical to Digital: Hoarding Phenomena in Obsessive-Compulsive Disorder

May 14, 2026

This case illustrates how hoarding phenomenology can manifest in digital environments, which offer virtually unlimited storage, anonymity, and low visibility.

Mitali Anil Khatri, Indira Naskar, Saurav Kumar, et al

Aripiprazole-Induced Pathological Gambling

Case Report

Aripiprazole-Induced Pathological Gambling

May 7, 2026

A 27-year-old man with a history of substance abuse developed a new-onset compulsive gambling pattern within weeks of starting aripiprazole.

Marta Ribeiro, Ana Lourenço, Inês Chaves

Clozapine-Associated Pulmonary Embolism

Case Report

Clozapine-Associated Pulmonary Embolism

May 5, 2026

A 48-year-old woman with schizoaffective disorder taking clozapine developed acute pulmonary embolism despite negative D-dimer results.

Kader Semra Karatas, Ceyhun Yilmaz

Polydipsia-Related Hyponatremia in Autism

Case Report

Polydipsia-Related Hyponatremia in Autism

April 30, 2026

The authors present the case of a 10-year-old boy with autism who presented to the ED with hyponatremia-related seizures due to compulsive water drinking.

Ahmed Naguy, Saxby Pridmore, Hessah H. Abul, et al

Diphenhydramine and Dextromethorphan Overdose

Case Report

Diphenhydramine and Dextromethorphan Overdose

April 28, 2026

The authors describe a case of intentional overdose with diphenhydramine and extended-release dextromethorphan-guaifenesin that initially presented with anticholinergic toxicity and later evolved into serotonin toxicity.

Ann C. Schwartz, Nicole K. Delgado, Gregg A. Robbins-Welty

Psychotropic-Induced Reversible Cerebral Vasoconstriction Syndrome

Case Report

Psychotropic-Induced Reversible Cerebral Vasoconstriction Syndrome

April 23, 2026

This case reinforces the importance of monitoring for acute neurologic symptoms in patients treated with high-dose selective serotonin reuptake inhibitors.

Michelle Savoldy, Katarina Bojkovic, Cory Klippel, et al

Osmotic Demyelination Syndrome Presenting as EPS

Case Report

Osmotic Demyelination Syndrome Presenting as EPS

April 21, 2026

A 44-year-old woman was initially referred for presumed domperidone-induced extrapyramidal symptoms, but further workup uncovered a complex interplay of hyponatremia, demyelination, and neuroleptic hypersensitivity.

Vivek Pant, Astha Jain, Shobit Garg, et al

Cultural Manifestations of Bereavement in a Chinese American Patient

Case Report

Cultural Manifestations of Bereavement in a Chinese American Patient

April 16, 2026

The authors highlight the difficulties of applying western psychiatric concepts to cultural minorities, as seen in a case of complicated bereavement in a 54-year-old Chinese American woman.

Larry Wang, Kelsey Kershaw, Jun Hwan Kim, et al

7-OH-Mitragynine–Induced Psychosis

Case Report

7-OH-Mitragynine–Induced Psychosis

April 14, 2026

The authors present the case of a patient who developed psychosis and delirium following several months of heavy 7-OH use that persisted for nearly a week following cessation.

Nour S. Elrokhsi, Calvin K. Lam, Alëna A. Balasanova

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