Electroconvulsive Therapy Decreases Dopamine D<sub>2</sub> Receptor Binding in the Anterior Cingulate in Patients With Depression: A Controlled Study Using Positron Emission Tomography With Radioligand [<sup>11</sup>C]FLB 457

Tomoyuki Saijo, MD, PhD; Akihiro Takano, MD, PhD; Tetsuya Suhara, MD, PhD; Ryosuke Arakawa, MD, PhD; Masaki Okumura, MD; Tetsuya Ichimiya, MD, PhD; Hiroshi Ito, MD, PhD; and Yoshiro Okubo, MD, PhD

Results: There were no significant differences in D2 receptor binding between patients with MDD and controls. All 7 patients showed clinical improvements in response to ECT treatment (P < .001). Significant changes in D2 receptor binding, a mean of 25.2% reduction, were found in the right rostral anterior cingulate (AC) following ECT (P < .001).

J Clin Psychiatry 2010;71(6):793–799

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