Improving the Course of Illness and Promoting Continuation of Treatment of Bipolar Disorder
Martin B. Keller, MD
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The course and characteristics of the different types of bipolar disorder have profound implications
for its long-term prognosis and treatment. Patients with bipolar I disorder are symptomatically ill
nearly half the time and have a high probability of relapse. Bipolar II disorder is more chronic, more
depressive, and associated with more neuroticism and emotional instability between episodes than
bipolar I. Impaired psychosocial functioning and a high risk for suicide are common to all types of
bipolar disorder. The illness can be stabilized through pharmacotherapy and by patients maintaining
orderly patterns of life activities and using psychotherapy, psychoeducation, and mood charting. Adherence
to pharmacotherapy increases the duration of remission. Physicians can help improve adherence
by selecting medications with simple dosage regimens and educating patients and families about
the disorder and what to expect from medications.
J Clin Psychiatry 2004;65(suppl 15):10-14
© Copyright 2004 Physicians Postgraduate Press, Inc.
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