Treatment-Resistant Self-Mutilation, Tics, and Obsessive-Compulsive Disorder in Neuroacanthocytosis: A Mouth Guard as a Therapeutic Approach

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The term neuroacanthocytosis describes a group of phenotypically and genetically heterogeneous disorders associated with choreatic movements, psychiatric abnormalities, and cognitive decline. Patients with neuroacanthocytosis may develop dementia, schizophrenia, obsessive-compulsive disorder (OCD), tourettism, and self-mutilation. We present the case of a patient with neuroacanthocytosis who developed treatment-resistant oral self-mutilation behaviors, phonic tics, OCD, and a severe lack of initiative (i.e., abulia).

J Clin Psychiatry 2008;69(7):1186-1187