The article you requested is
Mechanism of Action of Agents Used in Attention-Deficit/Hyperactivity Disorder
J Clin Psychiatry 2006;67(suppl 8):32-37
© Copyright 2015 Physicians Postgraduate Press, Inc.
Several medications have been demonstrated effective in treating individuals with attention-deficit/hyperactivity disorder (ADHD). There appears to be some commonality in the physiologic
mechanisms of action of these agents relevant to the treatment of ADHD. Either direct or indirect attenuation
of dopamine and norepinephrine neurotransmission appears related to both the stimulant
and nonstimulant medications efficacious in ADHD. However, important differences exist both between
and within the specific classes of agents. Elucidating the various mechanisms of action of
ADHD medications may lead to better choices in matching potential response to the characteristics
(e.g., genotype) of individuals.