A Positive Association Between Homeostasis Model Assessment of Insulin Resistance Score and the Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene in Schizophrenia Patients in Taiwan

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Objective: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan.

Method: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction–restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance.

Results: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = −0.65, P = .033).

Conclusions: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.

Prim Care Companion J Clin Psychiatry 2010;12(4);e1–e5

Submitted: November 1, 2009; accepted November 30, 2009.

Published online: August 19, 2010 (doi:10.4088/PCC.09m00918yel).

Corresponding author: Tsuo-Hung Lan, MD, PhD, Department of Psychiatry, Taichung Veterans General Hospital, No. 200, Sec. 1, DongDa Rd, Taichung 407, Taiwan (tosafish@hotmail.com).

Prim Care Companion J Clin Psychiatry 2010;12(4):e1-e5

https://doi.org/10.4088/PCC.09m00918yel