Neurobiology of Generalized Anxiety Disorder
Murray B. Stein, MD, MPH
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Generalized anxiety disorder (GAD) is a common illness with diagnostic criteria that have
changed substantially over time. Symptoms of GAD overlap with those of major depressive disorder
to such an extent that studying one disorder without studying the other may be impossible. Such an
overlap, combined with potentially inappropriate diagnostic criteria for GAD, makes diagnosing and
researching GAD challenging. Recent research into the genetics and neural circuitry of GAD may
suggest solutions for the disorder’s diagnostic controversies and point the way to productive future
studies of etiology and pathophysiology.
J Clin Psychiatry 2009;70(suppl 2):15-19
© Copyright 2009 Physicians Postgraduate Press, Inc.
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