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Keeping ’Em Honest: The Current Crisis of Confidence in Antidepressants

J Clin Psychiatry 2011;72(7):1015 [letter]

Letter to the Editor

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

On May 14, 2010, Dr Andrew A. Nierenberg assembled a roundtable conference of experts to address “the current crisis of confidence in antidepressants.” In the Journal commentary that resulted from this conference, Dr Nierenberg comments, “It is difficult for us to understand the popular perception that industry trials are biased….”

The problem may not be so much that data from industry trials may not be validly obtained, but, more insidiously, that they may be “spun” by the authors who frequently report small, albeit statistically significant, differences as if they are clinically relevant when they often are not.