Fluvoxamine Attenuates Panic Induced by 35% CO2 Challenge

Background: The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-IIIR panic disorder with agoraphobia.

Method: The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment.

Results: The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment.

Conclusion: The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.

J Clin Psychiatry 1996;57(11):539-542