Clozapine-Benzodiazepine Interactions

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Letter to the Editor

Sir: Clozapine is an atypical antipsychotic often used in the treatment of refractory schizophrenic patients. The manufacturer recommends caution when combining clozapine therapy with other CNS-active drugs, particularly benzodiazepines. Sassim and Grohmann first reported two cases of severe collapse with this combination. The first patient was a 51-year-old man on diazepam 20 mg/day.

J Clin Psychiatry 1997;58(12):547-548 [letter]