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Not So Selective Serotonin Reuptake Inhibitors

J Clin Psychiatry 1998;59(7):333-343
Selective serotonin reuptake inhibitors (SSRIs) got this name from their greater selectivity (10-fold or more) for blocking serotonin reuptake rather than norepinephrine reuptake. They also lack the sodium channel blocking properties of the tricyclic antidepressants, making them safe in overdose. In addition, SSRIs have less affinity for α1-receptors, muscarinic cholinergic receptors, and histamine-1 receptors compared with the tricyclic antidepressants, leading to the greater tolerability profile of SSRIs.