Introduction. Newer Drugs for Older Patients

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The entry of chlorpromazine into the psychopharmacologic armamentarium against schizophrenia and other psychotic disorders in 1952 started a new era in psychiatric management of severely mentally ill people. Chlorpromazine and other neuroleptic or antipsychotic drugs that followed it controlled the positive symptoms of psychosis such as delusions and hallucination far better than any of the previous treatments ever did. Equally importantly, they markedly reduced the risk of relapse in patients with chronic schizophrenia, schizoaffective disorder, and related conditions.​

J Clin Psychiatry 1999;60(suppl 13):3-4