Clozapine Versus Chlorpromazine in Geriatric Patients

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Letter to the Editor

Sir: I began my career in clinical research conducting multicenter comparative drug studies of antipsychotic agents in geriatric Veterans Affairs hospital patients. Thus, it was with high expectations that I read the article by Howanitz et al. comparing the old gold standard, chlorpromazine, with the new gold standard, clozapine, in a geriatric Veterans Affairs hospital patient population.

I was disappointed to find, however, certain problems with the authors’ interpretations of their study results.

J Clin Psychiatry 2000;61(1):63-64