Clozapine in the Treatment of Neuroleptic-Induced Blepharospasm: A Report of 4 Cases
J Clin Psychiatry 2000;61(2):140-143
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Background: Blepharospasm, the forcible closure
of eyelids, is an infrequent consequence of neuroleptic treatment
that, when severe, can interfere with the ability to walk, drive,
or work. Like tardive dyskinesia, blepharospasm can be
disfiguring and aesthetically distressing, contributing to the
increased stigmatization of patients.
Case Reports: We report 4 patients with DSM-IV
schizoaffective disorder, paranoid schizophrenia, or chronic
undifferentiated schizophrenia who developed neuroleptic-induced
blepharospasm. In all patients, blepharospasm remitted without
the reemergence of psychosis within 3 to 5 months of treatment
with clozapine, 100-200 mg/day.
Conclusion: The results suggest that clozapine
may successfully treat neuroleptic-induced blepharospasm without
the reemergence of psychosis in patients with schizophrenia,
schizoaffective disorder, or schizophreniform disorder.