Genetic Studies of Panic Disorder: A Review
J Clin Psychiatry 2000;61:756-766
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: A review of the studies examining
the genetic etiology of panic disorder shows the familial nature
of the disorder and demonstrates that the etiology is greatly
influenced by genetic factors. Strong evidence for vertical
transmission in family studies led to molecular genetic studies,
of which association designs appear promising, particularly when
based on trait markers.
Data Sources: The MEDLINE and PsycLIT databases
were searched for all reports published between 1966 and 2000
containing the keywords panic, genetic, twin, adoption,
linkage, association, and QTL.
Conclusion: We conclude that the multifactorial
nature of panic disorder requires a multidisciplinary approach to
gain insight into the determinants of the phenotype and the
interaction of environmental and genetic factors.