Pharmacotherapy of Posttraumatic Stress Disorder: Treatment Options, Long-Term Follow-Up, and Predictors of Outcome

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Posttraumatic stress disorder (PTSD) is a prevalent and disabling condition. Treatment is essential to reduce symptoms, increase the patient’s functioning and well-being, and reduce comorbidity with other psychological disorders. Evidence suggests that psychopharmacologic therapy can be effective in PTSD. This article considers clinical data for various pharmacologic treatment options for PTSD; in particular, several recent studies of selective serotonin reuptake inhibitors are examined. The longterm effects of pharmacotherapy and issues concerning patient management are also discussed.

J Clin Psychiatry 2000;61(suppl 5):52-56