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Antidepressant-Associated Mania and Psychosis Resulting in Psychiatric Admissions

J Clin Psychiatry 2001;62:30-33

Background: The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs.

Method: All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed.

Results: Forty-three (8.1%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis.

Conclusion: Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.