Antidepressant-Associated Mania and Psychosis Resulting in Psychiatric Admissions
J Clin Psychiatry 2001;62:30-33
© Copyright 2014 Physicians Postgraduate Press, Inc.
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Background: The safety and tolerability of the
selective serotonin reuptake inhibitors and the newer atypical
agents have led to a significant increase in antidepressant use.
These changes raise concern as to the likelihood of a
corresponding increase in adverse behavioral reactions
attributable to these drugs.
Method: All admissions to a university-based
general hospital psychiatric unit during a 14-month period were
Results: Forty-three (8.1%) of 533 patients were
found to have been admitted owing to antidepressant-associated
mania or psychosis.
Conclusion: Despite the positive changes in the
side effect profile of antidepressant drugs, the rate of
admissions due to antidepressant-associated adverse behavioral
effects remains significant.