Reply to "Possible Impact of Dropout in a Study ofHigh-Dose Olanzapine and Prolactin Levels"

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Sir: While we agree that dropouts could potentially influence this type of study, in this particular study they did not. All patients were from the senior author’s (J.L.K.’s) clinical practice, and no patient meeting the inclusion criteria dropped out. All patients had to be taking at least 20 mg/day of olanzapine for at least 4 months. Furthermore, any patient who would have dropped out prior to meeting inclusion criteria could not have been considered to be on high-dose, long-term treatment. This study was not intended to address the issue of prolactin elevation after low-dose or short-term treatment with olanzapine.

J Clin Psychiatry 2004;65(8):1150