Ondansetron Treatment in Tourette's Disorder: A 3-Week, Randomized, Double-Blind, Placebo-Controlled Study
J Clin Psychiatry 2005;66(4):499-503
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Objective: The aim of the present study was to
evaluate the efficacy of ondansetron, a selective 5-HT3 antagonist, in the treatment of Tourette's disorder.
Method: Participants (N = 30) aged 12 to 46 years,
diagnosed with DSM-IV Tourette's disorder and resistant to
previous haloperidol treatment, were enrolled in a 3-week,
randomized, double-blind, placebo-controlled outpatient study.
Assessments were conducted at baseline and once a week during the
study period. Scales used included the Tourette's Syndrome Global
Scale (TSGS), the Yale Global Tic Severity Scale (YGTSS), and the
Yale-Brown Obsessive Compulsive Scale. Ondansetron dose was 8,
16, and 24 mg/day in the first, second, and third weeks,
Results: A significant positive effect of
ondansetron on tic severity, as assessed by the TSGS, was noted
(baseline vs. endpoint: mean ± SD = 29.62 ± 20.33 vs. 20.58 ± 12.82,
p = .002 vs. placebo). However, no significant effect was detected
upon assessing ondansetron/placebo effect on tic severity with
the YGTSS (baseline vs. endpoint: mean ± SD = 24.04 ± 9.44 vs.
17.50 ± 9.48, p = .15 vs. placebo). No change in
obsessive-compulsive symptoms was noted in either group. Adverse
effects included mild and transient abdominal pain.
Conclusions: Ondansetron may have anti-tic
effects in patients with Tourette's disorder. Large-scale,
double-blind studies should further assess the anti-tic efficacy