Allergic Reaction to Depot Risperidone but Not to Oral Risperidone
J Clin Psychiatry 2005;66(7):949-949 [letter]
© Copyright 2017 Physicians Postgraduate Press, Inc.
Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.
Oral risperidone is an effective and well-tolerated atypical
antipsychotic1 that has been in widespread clinical usage for
over 10 years. In recent years, a long-acting injectable form of
depot risperidone with a delivery system different from other
depot antipsychotics became available in the United States
following several years of marketing in other countries. This
formulation consists of risperidone microencapsulated in 7525
polylactide-co-glycolide (PLG) at a concentration of 381 mg
of risperidone per gram of microspheres2
; the PLG slowly hydrolyzes
to release risperidone, allowing administration every