Effects of Antipsychotic Treatment on Tardive Dyskinesia: A 6-Month Evaluation of Patients From the European Schizophrenia Outpatient Health Outcomes (SOHO) Study
J Clin Psychiatry 2005;66(9):1130-1133
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Objective: To compare the incidence and
persistence of tardive dyskinesia between patients diagnosed with schizophrenia (ICD-10
and/or DSM-IV) who were treated with second-generation antipsychotics and first-generation
antipsychotics in routine clinical practice.
Method: The European Schizophrenia
Outpatient Health Outcomes (SOHO) study is a
3-year, prospective, observational study. Each
country had a start date for patient enrollment before
October 2000. All enrollment was completed by June 30, 2001. A simple, global measure of
tardive dyskinesia was rated by participating
clinicians. For the current analysis, data at baseline,
3 months, and 6 months were analyzed using a generalized estimating equation model.
antipsychotics conferred a lower risk for tardive dyskinesia at
6 months than first-generation antipsychotics
(0.9% vs. 3.8%, odds ratio [OR] = 0.29, 95%
confidence interval [CI] = 0.18 to 0.46). In addition,
patients with tardive dyskinesia at baseline who were
receiving second-generation antipsychotics were less likely than patients receiving
first-generation antipsychotics to have tardive dyskinesia
symptoms at 6 months (43.6% vs. 60.8%, OR = 0.50, 95% CI = 0.30 to 0.85). A sensitivity
analysis suggested no bias related to pharmaceutical
industry financial support.
Conclusion: The results suggest that the
relative advantage of second-generation antipsychotics in terms of lower rates of incidence
and persistence of tardive dyskinesia, observed in technical randomized controlled trials,
generalizes to routine clinical care.