Olanzapine Versus Risperidone in Newly Admitted Acutely Ill Psychotic Patients
J Clin Psychiatry 2005;66(12):1564-1568
© Copyright 2014 Physicians Postgraduate Press, Inc.
Purchase This PDF for $40.00
If you are not a paid subscriber, you may purchase the PDF.
(You'll need the free Adobe Acrobat Reader.)
Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($86) or print + online ($156 individual).
With your subscription, receive a free PDF collection of the NCDEU Festschrift articles. Hurry! This offer ends December 31, 2011.
If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
Click here to login.
Did you forget your password?
Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send email
Objective: Risperidone and olanzapine are
the 2 most widely prescribed second-generation
antipsychotics. The purpose of this study was to
compare the efficacy of risperidone and olanzapine using duration of hospitalization as the
primary outcome measure. This outcome was selected
as it is an indirect measure of how well patients
are responding to the medication and represents a "real world" endpoint relevant to practicing
Method: The study was done at a large
state psychiatric hospital in North Carolina from
2001 to 2003. Subjects were eligible for inclusion
if they required treatment with an antipsychotic (e.g., positive symptoms) and were able to
provide informed consent. Eighty-five patients entered the study and were randomly assigned
to risperidone (N = 40) or olanzapine (N = 45) as
their initial antipsychotic. Treatment was
naturalistic, and dosing was based on the discretion of
the treating physician.
Results: There was no significant difference
in the mean durations of hospitalization for the
risperidone group (7.9 days) as compared to the olanzapine group (8.1 days). There were no
significant differences in the demographics of
either treatment group, but, during the study,
risperidone-treated patients used more
antihistamines (chi2 = 4.0, p = .05). Eighty percent of each
group (N = 36, olanzapine; N = 32, risperidone)
remained on the study medication at discharge.
Conclusions: Risperidone and
olanzapine were equally efficacious, suggesting that
measures other than "efficacy" (e.g., side
effects, cost) should be considered when
determining overall "effectiveness" of treatment.