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The Effect of Stimulant Treatment for ADHD on Later Substance Abuse and the Potential for Medication Misuse, Abuse, and Diversion
J Clin Psychiatry 2007;68(11):e28
© Copyright 2015 Physicians Postgraduate Press, Inc.
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Attention-deficit/hyperactivity disorder (ADHD) is known to
be a strong risk factor for substance use disorders (SUD) in adolescence and in
adulthood. Research shows that stimulant treatment does not increase the risk
of SUD in adolescents or adults with ADHD but rather that stimulant treatments
may have a protective effect. However, 2 in 10 youths with ADHD misuse their
medication. Recent evidence suggests that slow uptake of medication in the
brain allows for effective treatment without patients experiencing the euphoric
qualities of immediate-release agents that lead to abuse or diversion. As a
result, extended-release products and different formulations, such as
lisdexamfetamine dimesylate (LDX), are less likely to be misused and diverted
and may have lower abuse potential.
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