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Please answer the following questions about schizophrenia.

1. Decreased activity at NMDA glutamate synapses may account for which of the following symptoms of schizophrenia:

Delusions and hallucinations

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All of the above

2. Mr F, an overweight 40-year-old patient with schizophrenia, presents with extrapyramidal side effects (EPS) on his current dose of haloperidol. Based on the mechanism of action of the following antipsychotics, which drug type would be the best choice to resolve Mr F’s EPS without worsening his weight gain?

An antipsychotic with the strongest affinity for dopamine receptors (eg, perphenazine)

An antipsychotic with tighter binding to histamine receptors than to dopamine receptors (eg, olanzapine, clozapine)

An antipsychotic with tighter blockade to serotonin than dopamine (eg, risperidone, ziprasidone)

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Journal Archive

Science, Rhetoric, and the End of Psychosis
Andrew James Amos, MBBS

Dr Amos voices his concerns about bias in the early intervention in psychosis literature. He welcomes your comments.

» Read this post

» Read the entire blog

Monitoring Pharmacotherapy Response, Safety, and Tolerability in Bipolar Disorder
Paul E. Keck, Jr., MD

New! Find out about assessing treatment response, monitoring safety and tolerability, and treating metabolic abnormalities.

>>See the entire activity

Submit original research, review articles, case reports, brief reports, commentaries, rounds, and letters. Typical topics include depression, anxiety, dementia, MS, ADHD, and sleep disorders.

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Published Online 04-17-14

Mixed Specifier for Bipolar Mania and Depression: Highlights of DSM-5 Changes and Implications for Diagnosis and Treatment in Primary Care [CME]

[Abstract] [Full Text] [CME Posttest]

Published Online 04-03-14

Acute Interventions and Referral of Patients With Bipolar Disorder by the Psychiatric Consultation Liaison Service in a General Hospital in Germany: A Retrospective Analysis

[Abstract] [Full Text]

Published Online 03-27-14

Association of Hypnotics With Stroke Risk: A Population-Based Case-Control Study

[Abstract] [Full Text]

Published Online 03-06-14

A Survey of Patients’ Knowledge About Lithium Therapy in the Elderly

[Abstract] [Full Text]

Features & Letters

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Published Online 04-17-14

Letter to the Editor: Lithium-Induced Fixed Drug Eruption in a Case of Bipolar Mania

[Full Text]

Published Online 04-10-14

Brief Report: Negative Rumor: Contagion of a Psychiatric Department

[Full Text]

Published Online 04-03-14

Letter to the Editor: Nystagmus as a Discontinuation Symptom After Antidepressant Therapy: A Case Report

[Full Text]

Published Online 03-27-14

Letter to the Editor: A Case Report of the Use of Vilazodone in Pregnancy

[Full Text]

Published Online 03-20-14

Letter to the Editor: A New Perspective on Gender Dysphoria and Repetitive Sex Reassignment Surgeries: A Case Report

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Published Online 03-13-14

Rounds in the General Hospital: Psychotic Disorders in Children and Adolescents: A Primer on Contemporary Evaluation and Management

[Full Text]

Letter to the Editor: DSM-5 Drops the 5 Axes of Mysticism: A Supportive Survey

[Full Text]

Published Online 03-06-14

Letter to the Editor: Secondary Psychosis 3 Months Prior to the Overt Symptoms of Multiple Myeloma: A Case Report

[Full Text]

Current Issue

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Volume 162014Number 1

Editorial

A New Era of Collaboration for Primary Care and Psychiatry

[Full Text]

Articles

Effect of Probiotic Supplementation on Schizophrenia Symptoms and Association With Gastrointestinal Functioning: A Randomized, Placebo-Controlled Trial

[Abstract] [Full Text] [Listen]

A Review of Spin and Bias Use in the Early Intervention in Psychosis Literature

[Abstract] [Full Text] [Listen]

Clinical Relevance of Vilazodone Treatment in Patients With Major Depressive Disorder: Categorical Improvement in Symptoms [Free PDF]

[Abstract] [Full Text] [Listen]

Efficacy and Safety of Low-Dose Doxepin in Depressed Patients Suffering From Insomnia: A Retrospective, Naturalistic Case Series Analysis

[Abstract] [Full Text] [Listen]

A Review of Vilazodone, Serotonin, and Major Depressive Disorder [Free PDF]

[Abstract] [Full Text] [Listen]

Prevalence of Substance Misuse in New Patients in an Outpatient Psychiatry Clinic Using a Prescription Monitoring Program [Free PDF]

[Abstract] [Full Text] [Listen]

Rounds From Banner Alzheimer's Institute

Out of Sight, Out of Mind: The Case of a 62-Year-Old Man With Visual Complaints and Cognitive Decline [CME]

[Full Text] [Posttest] [Listen]

Psychotherapy Casebook

How to Live With a Terminal Illness

[Full Text]

Letters to the Editor

A Case of Mouthwash as a Source of Ethanol Poisoning: Is There a Need to Limit Alcohol Content of Mouthwash?

[Full Text]

Capgras’ Syndrome in an Elderly Patient With Dementia

[Full Text]

Behavioral Management of Tourette’s Disorder in a 5-Year-Old Child

[Full Text]

A Case of Psychogenic Non-Epileptic Seizures, Unresponsive Type, in Pregnancy

[Full Text]

A Case of Reversible Erectile Dysfunction With Topiramate for Alcohol Dependence

[Full Text]

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Special Sections

Out of Sight, Out of Mind: The Case of a 62-Year-Old Man With Visual Complaints and Cognitive Decline

Saurav Das, MBBS; Adam S. Fleisher, MD, MAS; Roy Yaari, MD, MAS; James D. Seward, PhD, ABPP; Anna D. Burke, MD; Helle Brand, PA; and Pierre N. Tariot, MD

This issue highlights the case of a 62-year-old man with 3 years of gradually progressive difficulties with cognition and vision problems. He is misplacing items and having trouble completing sentences, reading and writing, and staying on task. Does this patient have visual agnosia, mild cognitive impairment, or Alzheimer’s disease?

>>See the entire activity

>>See all available Rounds

Helplessness in the Helpers: Etiology and Management

Erik W. Larsson and Theodore A. Stern

Certain clinical situations can make a caregiver feel helpless; however, feelings of helplessness can be overcome by dividing an overwhelming situation into its smaller and more manageable components. By analyzing and interpreting their own psychological reactions, clinicians can often gain valuable insights into their patients.

>>See the entire article

>>See all available Rounds

Residual Symptoms in Major Depressive Disorder: Prevalence, Effects, and Management

John Zajecka, Susan G. Kornstein, and Pierre Blier

Even after achieving response or remission, patients with MDD often have residual symptoms that negatively affect their functioning and quality of life. Here, find out about the neurochemical mechanisms involved in MDD, how to identify residual depressive symptoms, and formulate a long-term treatment plan so that you can target interventions to promote optimal outcomes for each patient.

>>See the entire activity

>>See all available PCC Academic Highlights

How to Live With a Terminal Illness

Dean Schuyler

Read the case of Mr A, a 70-year-old man with amyotrophic lateral sclerosis, who learned to adjust to the progressive course of his illness through psychotherapy.

>>See the entire article

>>See all available Psychotherapy Casebook articles

CME activity

CME

Measurement-Based Strategies to Assess and Manage Schizophrenia

Leslie Citrome, MD, MPH (Chair), et al

New! In this Supplement, discover how to distinguish between primary and secondary negative symptoms, find out how to assess treatment response and functioning, and review new therapeutic targets in the treatment of schizophrenia.

>>See the entire activity

>>See all Journal CME activities

Recognizing Residual Depressive Symptoms

Maurizio Fava, MD

Learn how to assess your patients' response to treatment and recognize residual symptoms so that you can implement appropriate next-step strategies.

>>See the entire activity

>>See all Multimedia activities

Switching Antipsychotic Medications to Reduce Adverse Event Burden in Schizophrenia: Establishing Evidence-Based Practice

John W. Newcomer, MD (Chair), et al

New! In this Brief Report series, experts discuss the management of adverse effects via elective changes in oral antipsychotics and provide updated guidance based on recent research findings.

>>See the entire activity

>>See all Special Features

Learn. Practice. Treat.

Differential Diagnosis of Unipolar Vs Bipolar Depression

Larry Culpepper, MD, MPH

Read about 2 effective tools for screening for bipolar disorder and how to use them throughout treatment to recognize red flags that indicate this illness.

>>See the entire activity

>>See related activities

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