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Commentary: High-Dose Olanzapine for Treatment-Resistant Schizophrenia

J Clin Psychiatry 2008;69(2):176-177

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In this issue of the Journal, Meltzer et al.1 present provocative results from a randomized, double-blind I study showing that larger-than-typically-prescribed doses of olanzapine appear to be equivalent to conventional doses of clozapine in treatment-resistant schizophrenia. Although the sample size is relatively small (total N = 40), the data are consistent with the notion that highdose olanzapine might be effective in treatment-resistant schizophrenia. These findings are important because they open up the possibility of a new approach to treatmentresistant schizophrenia.​​