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Academic Highlights: A Roadmap to Key Pharmacologic Principles in Using Antipsychotics in the Treatment of Bipolar Disorder

J Clin Psychiatry 2008;69(7):1176-1183

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​On the basis of the National Comorbidity Survey Replication (NCS-R), it is estimated that bipolar I and II disorders may affect nearly 3% of the population (i.e., 5.7 million Americans), with the prevalence of subthreshold but still impairing bipolar presentations estimated to be even higher. Bipolar disorder is associated with significant functional impairment and elevated health care costs. Although unipolar depression appears to be over 6 times as prevalent as bipolar disorder, NCS-R data found that the costs of bipolar disorder to the U.S. workplace, estimated at $14.1 billion annually, were almost half the cost of lost productivity associated with unipolar depression.​