Second-Generation Antipsychotic-Associated Diabetes Mellitus and Diabetic Ketoacidosis: Mechanisms, Predictors, and Screening Need (ASCP Corner)

Antipsychotic medications, as well as schizophrenia, have been associated with an increased risk for diabetes. However, the relative contributions of the underlying illness, unhealthy lifestyle behaviors, and medications used to treat schizophrenia are still unclear. Although first- and second-generation antipsychotics have been contrasted broadly in the literature regarding their risks for glucoregulatory abnormalities, there is now sufficient evidence to suggest that the risk for diabetes is not uniform within each antipsychotic class.

J Clin Psychiatry 2009;70(5):765-766