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ASCP Corner

Metabolic Side Effects of Second-Generation Antipsychotics in Children and Adolescents: A Different Story?

Christoph U. Correll, MD

Published: October 14, 2005

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In many clinical settings, secondgenerationantipsychotics are preferred overfirst-generation antipsychotics because theycause fewer acute1 and chronic2 neuromotorside effects. In addition, second-generationantipsychotics may have improved3,4 andbroader5 efficacy and are potentially associatedwith somewhat lower rates of nonadherence6compared with those of the olderagents. However, since the late 1990s, the increasedrisk for weight gain associated withsecond-generation antipsychotics has becomea focus of attention.’ ‹’ ‹

Volume: 66

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