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Selective Serotonin Reuptake Inhibitors and Persistent Pulmonary Hypertension of the Newborn

J Clin Psychiatry 2012;73(5):e601-e605
10.4088/JCP.12f07731

A young woman with recurrent major depressive disorder has been reasonably stable on sertraline (150 mg/day) for 2 years. She is childless and plans to conceive, and a risk-benefit analysis suggests that she would do well to continue her medication during pregnancy. Having learned that a new study has shown that her medication doubles the risk of persistent pulmonary hypertension of the newborn (PPHN), she seeks a fresh opinion. This article discusses the methods, findings, strengths, and limitations of the new study and provides information which will help her physician answer the questions that she asks.